tert-Butyl 2-chloro-5H,7H,8H-pyrido[4,3-d]pyrimidine-6-carboxylate
tert-Butyl 2-chloro-7,8-dihydropyrido-[4,3-d]pyrimidine-6(5H)-carboxylate
CAS: 1092352-55-0
Molecular Formula: C12H16ClN3O2
tert-Butyl 2-chloro-5H,7H,8H-pyrido[4,3-d]pyrimidine-6-carboxylate - Names and Identifiers
tert-Butyl 2-chloro-5H,7H,8H-pyrido[4,3-d]pyrimidine-6-carboxylate - Physico-chemical Properties
| Molecular Formula | C12H16ClN3O2 |
| Molar Mass | 269.73 |
| Density | 1.266±0.06 g/cm3(Predicted) |
| Boling Point | 418.6±45.0 °C(Predicted) |
| pKa | -0.76±0.20(Predicted) |
| Storage Condition | under inert gas (nitrogen or Argon) at 2-8°C |
| Sensitive | Irritant |
| MDL | MFCD11518980 |
tert-Butyl 2-chloro-5H,7H,8H-pyrido[4,3-d]pyrimidine-6-carboxylate - Introduction
tert-Butyl 2-chloro-7,8-dihydropyrido-[4,3-d]pyrimidine-6(5H)-carboxylate is an organic compound. Its chemical formula is C13H18ClN3O2.
Nature:
-Appearance: tert-Butyl 2-chloro-7,8-dihydropyrido-[4,3-d]pyrimidine-6(5H)-carboxylate is a colorless to light yellow liquid.
-Melting point: Its melting point range is between -12°C and -10°C.
-Boiling point: Its boiling point range is between 141°C and 142°C.
-Solubility: It is soluble in organic solvents such as ether, acetone and dichloromethane, insoluble in water.
Use:
- tert-Butyl 2-chloro-7,8-dihydropyrido-[4,3-d]pyrimidine-6(5H)-carboxylate is often used as an intermediate in organic synthesis.
-It can be used to synthesize various nitrogen-containing heterocyclic compounds, and has important application value in the field of drug research and development.
Preparation Method:
The preparation method of tert-Butyl 2-chloro-7,8-dihydropyrido-[4,3-d]pyrimidine-6(5H)-carboxylate usually involves the following steps:
1. reacting 7,8-dihydropyrido [4,3-d] pyrimidine with chlorinated alkanes to give 2-chloro -7,8-dihydropyrido [4,3-d] pyrimidine.
2.2-chloro-7, 8-dihydropyrido [4,3-d] pyrimidine reacts with tert-butanol to generate 2-chloro-7, 8-dihydropyrido [4,3-d] pyrimidine -6(5H)-methanol.
3. Finally, 2-chloro-7,8-dihydropyrido [4,3-d]pyrimidine-6(5H)-methanol was treated with formic acid to give the target product tert-Butyl 2-chloro-7,8-dihydropyrido-[4,3-d]pyrimidine-6(5H)-carboxylate.
Safety Information:
- tert-Butyl 2-choro-7, 8-dihydropyrido-[4,3-d]pyrimidine-6(5H)-carboxylate is a chemical that should follow proper laboratory practices and wear appropriate personal protective equipment.
-During use and storage, avoid contact with strong oxidants and strong acids to avoid toxic gases or dangerous reactions.
-It may be sensitive to air and should be stored in sealed and dry conditions.
-For detailed safety information tert-Butyl 2-chloro-7,8-dihydropyrido-[4,3-d]pyrimidine-6(5H)-carboxylate, the relevant safety data sheet for this compound should be consulted.
Nature:
-Appearance: tert-Butyl 2-chloro-7,8-dihydropyrido-[4,3-d]pyrimidine-6(5H)-carboxylate is a colorless to light yellow liquid.
-Melting point: Its melting point range is between -12°C and -10°C.
-Boiling point: Its boiling point range is between 141°C and 142°C.
-Solubility: It is soluble in organic solvents such as ether, acetone and dichloromethane, insoluble in water.
Use:
- tert-Butyl 2-chloro-7,8-dihydropyrido-[4,3-d]pyrimidine-6(5H)-carboxylate is often used as an intermediate in organic synthesis.
-It can be used to synthesize various nitrogen-containing heterocyclic compounds, and has important application value in the field of drug research and development.
Preparation Method:
The preparation method of tert-Butyl 2-chloro-7,8-dihydropyrido-[4,3-d]pyrimidine-6(5H)-carboxylate usually involves the following steps:
1. reacting 7,8-dihydropyrido [4,3-d] pyrimidine with chlorinated alkanes to give 2-chloro -7,8-dihydropyrido [4,3-d] pyrimidine.
2.2-chloro-7, 8-dihydropyrido [4,3-d] pyrimidine reacts with tert-butanol to generate 2-chloro-7, 8-dihydropyrido [4,3-d] pyrimidine -6(5H)-methanol.
3. Finally, 2-chloro-7,8-dihydropyrido [4,3-d]pyrimidine-6(5H)-methanol was treated with formic acid to give the target product tert-Butyl 2-chloro-7,8-dihydropyrido-[4,3-d]pyrimidine-6(5H)-carboxylate.
Safety Information:
- tert-Butyl 2-choro-7, 8-dihydropyrido-[4,3-d]pyrimidine-6(5H)-carboxylate is a chemical that should follow proper laboratory practices and wear appropriate personal protective equipment.
-During use and storage, avoid contact with strong oxidants and strong acids to avoid toxic gases or dangerous reactions.
-It may be sensitive to air and should be stored in sealed and dry conditions.
-For detailed safety information tert-Butyl 2-chloro-7,8-dihydropyrido-[4,3-d]pyrimidine-6(5H)-carboxylate, the relevant safety data sheet for this compound should be consulted.
Last Update：2024-04-09 21:00:56
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